Roger Rabbit sequel

This being the place I've posted besides the Warner Bros. section, here's something I'd like to discuss because it has been in development for a while--a sequel to one of my favorite films due to the brilliant mix of live-action and animation with cameos of classic cartoons characters such as Mickey Mouse and Bugs Bunny Who Framed Roger Rabbit. Since the guy who plays Eddie Valiant Bob Hoskins has recently announced he's retiring from acting due to him having Parkinson's disease, and it's got me wondering how they are going to do a sequel without him. My question for you guys is--how would you do a sequel to Who Framed Roger Rabbit? What time period should it be placed in? Which classic cartoon characters would you like to see again and which new ones should be used for the sequel(kindof depends on time period and which companies Disney is friendly with. )? How would you write this with the inclusion of Eddie Valiant? Have fun guys!