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Comedian Louie Anderson's bittersweet reminiscences about his childhood. He introduces the cartoon with a live- action bit at the top.

Louie Anderson, Andy Anderson, Tommy Anderson, Mrs. Ora Anderson, Michael Grunewald, Glen Glenn, Jeannie, Grandma

Life With Louie was a semi-autobiographical half-hour animated series based on the occasionally bittersweet childhood of comedian Louie Anderson. In the show, 8-year-old Louie lived at home with his mother, his father, and his little brother Tommy. Each episode began in live-action, with the real Louie Anderson introducing the show and setting up the episode's plot.

Life With Louie viewed the ordinary through the eyes of its title character, a slightly tubby kid with a deep voice (provided by Anderson himself). Louie was always trying to cheer up his father, a grumpy war veteran, while simultaneously taking care of himself and Tommy.

Although the series had its tender-hearted moments, the emphasis was definitely on the more comedic aspects of growing up, like playing practical jokes on little Tommy and pursuing neighborhood cutie Jeannie Harper.

A major hit on Fox's Saturday morning lineup, Life With Louie showed us what a little laughter could do change a difficult situation.