Cramps

Jeff (the short one) sleeps in a bed with Mutt (talk about homoerotic!). He's awakened by really bad stomach cramps, so his dimwit pal Mutt (the tall one) climbs down their fire escape in a very New Yorkesque scene to a pharmacy below, where he looks in a book and concocts some potions for Jeff to drink. When he screws up the formula, the cure is worse than the sickness. The results, as expected, are atrocious. At one point, Mutt sprays Jeff's mouth with a fire extinguisher!

Mutt (Augustus J. Mutt), Jeff (Edgar Horace Jeff)

Silent cartoon. This film has a brief section of footage showing Bud Fisher smiling for the camera before the cartoon starts.